nowin
30-09-07, 18:40
All American Pharmaceutical and Natural Foods Corp. (Billings, MT, USA)claim that Kre-alkalyn® (KA) a “Buffered” creatine, is 100% stable instomach acid and does not convert to creatinine. In contrast, they alsoclaim that creatine monohydrate (CM) is highly pH labile with more than90% of the creatine converting to the degradation product creatinine instomach acids. To date, no independent or university laboratory hasevaluated the stability of KA in stomach acids, assessed its possibleconversion to creatinine, or made direct comparisons of acid stabilitywith CM.
Thisstudy examined whether KA supplementation reduced the rate of creatineconversion to creatinine, relative to commercially available CM(CreapureÒ).Creatine products were analyzed by an independent commercial laboratoryusing testing guidelines recommended by the United States Pharmacopeia(USP). Each product was incubated in 900ml of pH 1 HCL at 37± 1oC and samples where drawn at 5, 30 and 120 minutes and immediately analyzed by HPLC (UV) for creatine and creatinine.
Incontrast to the claims of All American Pharmaceutical and Natural FoodsCorp., the rate of creatinine formation from CM was found to be lessthan 1% of the initial dose, demonstrating that CM is extremely stableunder acidic conditions that replicate those of the stomach. This studyalso showed that KA supplementation actually resulted in 35% greaterconversion of creatine to creatinine than CM. In conclusion theconversion of creatine to creatinine is not a limitation in thedelivery of creatine from CM and KA is less stable than CM in the acidconditions of the stomach.
Universityof Northumbria, Sport Sciences, Northumbria University, NorthumberlandBuilding, Newcastle upon Tyne, United Kingdom, 2Department of Life Sciences, Kingston University, Penrhyn Rd, Kingston-upon-Thames, United Kingdom. DrTallon@CR-Technologies.net
chodzi mniej więcej o to że monohydrat praktycznie wogóle nie zmienia się w kreatynine w żołądku a krealkalyn w tak i to w 35%
pozostaje tylko kwestia wiarygodności badań
Thisstudy examined whether KA supplementation reduced the rate of creatineconversion to creatinine, relative to commercially available CM(CreapureÒ).Creatine products were analyzed by an independent commercial laboratoryusing testing guidelines recommended by the United States Pharmacopeia(USP). Each product was incubated in 900ml of pH 1 HCL at 37± 1oC and samples where drawn at 5, 30 and 120 minutes and immediately analyzed by HPLC (UV) for creatine and creatinine.
Incontrast to the claims of All American Pharmaceutical and Natural FoodsCorp., the rate of creatinine formation from CM was found to be lessthan 1% of the initial dose, demonstrating that CM is extremely stableunder acidic conditions that replicate those of the stomach. This studyalso showed that KA supplementation actually resulted in 35% greaterconversion of creatine to creatinine than CM. In conclusion theconversion of creatine to creatinine is not a limitation in thedelivery of creatine from CM and KA is less stable than CM in the acidconditions of the stomach.
Universityof Northumbria, Sport Sciences, Northumbria University, NorthumberlandBuilding, Newcastle upon Tyne, United Kingdom, 2Department of Life Sciences, Kingston University, Penrhyn Rd, Kingston-upon-Thames, United Kingdom. DrTallon@CR-Technologies.net
chodzi mniej więcej o to że monohydrat praktycznie wogóle nie zmienia się w kreatynine w żołądku a krealkalyn w tak i to w 35%
pozostaje tylko kwestia wiarygodności badań